1.
pyrophosphate hydrolysis: Potential mechanism for uremic vascular calcification Kidney International, 2008, 73, 1024–1030
2. Ziegler, S.; Chew, E.; Dietz, H.; Millan, J.-L.; Pinkerton, A. B.; Gahl, W.; Ferreira, C.; MacFarlane, E.; Riddle, R.;
Lomashvili, K.A.; Garg, P.; Narisawa, S.; Millan, J.L.; O’Neill, W. C. Upregulation of alkaline phosphatase and
Tomlinson, R.; Martin, L.; Ma, C.-T.; Sergienko, E. Ectopic calcification in pseudoxanthoma elasticum responds to inhibition of
tissue non-specific alkaline phosphatase Science Translational Medicine 2017, doi: 10.1126/scitranslmed.aal1669
3.
Osteoporosis Rep., 2017, DOI 10.1007/s11914-017-0370-3
4. St. Hilaire, C.; Ziegler, S.G.; Markello, T.C.; Brusco, A.; Groden, C.; Gill, F.; Carlson-Donohoe, H.; Lederman, R.J.;
Nitschke, Y.; Rutsch, F. Inherited Arterial Calcification Syndromes: Etiologies and Treatment Concepts Curr.
Chen, M.Y.; Yang, D.; Siegenthaler, M.P.; Arduino, C.; Mancini, C.; Freudenthal, B.; Stanescu, H.C.; Zdebik, A.A.;
Chaganti, R.K.; Nussbaum, R.L.; Kleta, R.; Gahl, W.A.; Boehm, M. NT5E Mutations and Arterial Calcifications New England
Journal of Medicine 2011, 364, 432-442
5. Villa-Bellosta, R.; Rivera-Torres, J.; Osorio, F.G; Acín-Pérez, R.; Enriquez, J.A; López-Otín, C.; Andrés, V. Defective
Extracellular Pyrophosphate Metabolism Promotes Vascular Calcification in a Mouse Model of Hutchinson-Gilford Progeria
Syndrome That Is Ameliorated on Pyrophosphate Treatment Circulation 2013, 127, 2442-2451.
6.
Sheen, C. R.; Kuss, P.; Narisawa, S.; Yadav, M. C.; Nigro, J.; Wang, W.; Chhea, T. N.; Sergienko, E. A.; Kapoor, K.;
Jackson, M. R.; Hoylaerts, M. F.; Pinkerton, A. B.; O’Neill, W. C.; Millan, J. L. Pathophysiological role of vascular smooth
muscle alkaline phosphatase in medial artery calcification Journal of Bone and Mineral Research 2015, 30 (5), 824-836.
7.
Savinov, A.Y.; Salehi, M.; Yadav, M.S.; Radichev, I.; Millan, J.L.; Savinova, O.V. Transgenic Overexpression of
Tissue-Nonspecific Alkaline Phosphatase (TNAP) in Vascular Endothelium Results in Generalized Arterial Calcification J Am
Heart Assoc. 2015;4:e002499 doi: 10.1161/ JAHA.115.002499
8.
Mebarek, S.; Hamade, E.; Thouverey, C.; Bandorowicz-Pikula, J.; Pikula, S.; Magne, D.; Buchet, R. Ankylosing
Spondylitis, Late Osteoarthritis, Vascular Calcification, Chondrocalcinonsis and Pseudo Gout: Toward a Possible Drug Therapy.
Current Medicinal Chemistry, 2011, 18, 2196-2203.
9.
treatment target for cardiovascular disease in CKD Nature Reviews Nephrology, 2017, 7, 429-442
10. Kozlenkov, A.; Le Du, M.H.; Cuniasse, P.; Ny, T.; Hoylaerts, M.F.; Millan, J.L. Residues Determining the Binding
Specificity of Uncompetitive Inhibitors to Tissue-Nonspecific Alkaline Phosphatase J. Bone Miner. Res. 2004, 19, 1862–1872.
Haarhaus, M.; Brandenburg, V.; Kalantar-Zadeh, K.; Stenvinkel, P.; Magnusson. P. Alkaline phosphatase: a novel
11.
Chang, L.; Do, L.D.; Mébarek, S.; Popowycz, F.; Pellet-Rostaing, S.; Lemaire, M.; Buchet, R. Bioorg. Med. Chem.
Lett. 2011, 21, 2297-2301.
12.
Debray, J.; Chang, L.; Marquès, S.; Pellet-Rostaing, S.; Do, L.D.; Mebarek, S.; Buchet, R.; Magne, D.; Popowycz, F.;
Lemaire, M. Inhibitors of tissue-nonspecific alkaline phosphatase: Design, synthesis, kinetics, biomineralization and cellular tests
Bioorg. Med. Chem. 2013, 21, 7981-7987.
13.
Marques, S.; Buchet, R.; Popowycz, F.; Lemaire, M.; Mebarek, S. Synthesis of benzofuran derivatives as selective
inhibitors of tissue-nonspecific alkaline phosphatase: effects on cell toxicity and osteoblast-induced mineralization Bioorg. Med.
Chem. Lett. 2016, 26, 1457-1459.
14.
Petrosyan, A.; Ghochikyan, T. V.; Ejaz, S. A.; Mardiyan, Z. Z.; Ullah Khan, S.; Grigoryan, T.; Gevorgyan, A.;
Samvelyan, M. A.; Galstyan, A. S.; Parpart, S.; Rahman, Q.; Iqbal, J.; Langer, P. Synthesis of Alkynylated Dihydrofuran-2(3H)-
ones as Potent and Selective Inhibitors of Tissue Non-Specific Alkaline Phosphatase ChemistrySelect 2017, 2, 5677-5683.
15.
Dahl, R.; Sergienko, E. A.; Su, Y.; Mostofi, Y. S.; Yang, L.; Simão, A. M.; Narisawa, S.; Brown, B.; Mangravita-
Novo, A.; Vicchiarelli, M.; Smith, L. H.; O’Neill, W. C.; Millán, J. L.; Cosford, N. D. Discovery and Validation of a Series of