Synthesis and stereochemistry of potential opioid-like 2,4-m-diarylsubstituted 3,7-diazabicyclo[3.3.1]nonan-9-one-1,5-diesters

Article abstract of DOI:10.1002/ardp.19923251008

The 2,4-di-2-pyridyl-substituted 7-methyl-3,7-diazabicyclo[3.3.1]nonan-9-one-1,5-diester shows a reasonable κ-agonistic activity in the mouse vas deferens test. - To enhance the analgetic activity derivatives with m-Cl-, m-CH₃-, m-OCH₃