Tetrahedron Letters p. 6127 - 6130 (1992)
Update date:2022-08-02
Topics: Asymmetric synthesis Column chromatography Yield NMR spectroscopy Nucleophile Electrophile Enantioselectivity Deprotonation Recrystallization Hydrolysis HPLC (high-performance liquid chromatography) Protecting group Workup Chiral Resolution Chiral Catalyst Reaction Optimization Stoichiometric Control Phosphonate α-aminophosphonic acids
Maury
Royer
Husson
A simple and general method for the asymmetric synthesis of α-aminophosphonic acids is described. A chiral phosphonate prepared in one step from R-(-)-phenylglycinol was alkylated with good diastereoselectivity using different electrophiles.
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