A simple and general method for the asymmetric synthesis of α-aminophosphonic acids

DOI: 10.1016/S0040-4039(00)60023-0

Source and publish data:

Tetrahedron Letters p. 6127 - 6130 (1992)

Update date:2022-08-02

Topics: Asymmetric synthesis Column chromatography Yield NMR spectroscopy Nucleophile Electrophile Enantioselectivity Deprotonation Recrystallization Hydrolysis HPLC (high-performance liquid chromatography) Protecting group Workup Chiral Resolution Chiral Catalyst Reaction Optimization Stoichiometric Control Phosphonate α-aminophosphonic acids

Authors:

Maury Maury

Royer Royer

Husson Husson

Read Full Text PDF DownLoad Join now for total 90,000,000 free articles

Article abstract of DOI:10.1016/S0040-4039(00)60023-0

A simple and general method for the asymmetric synthesis of α-aminophosphonic acids is described. A chiral phosphonate prepared in one step from R-(-)-phenylglycinol was alkylated with good diastereoselectivity using different electrophiles.

Full text of DOI:10.1016/S0040-4039(00)60023-0

Products guided by the article

Product name:[2-Phenyl-1-((R)-4-phenyl-oxazolidin-3-yl)-ethyl]-phosphonic acid dimethyl ester

Cas No:145240-89-7

R&D Labs maybe for 145240-89-7

NINGBO YINZHOU PRECISE COLOR CO.,LTD.

Contact:86-574-88139809 86-574-83033159

Address:Qiming Road,Yinzhou,Ningbo,China
zhangjiagang bonded areas banggao co;ltd

website:http://www.shunchangchem.com

Contact:0086-13921972933

Address:Dongsha Chemical Zone.Zhangjiagang, Jiangsu Province
zhuzhou zhongle chemical co. ltd.

Contact:+86-0731 28228409

Address:Zhuzhou, Hunan, China
Shanghai Sunwise Chemical Co., Ltd

website:http://www.sunwisechem.com

Contact:86-021-33883180

Address:Room 10E, Building G, Westlink Center, No. 2337 Gudai Road, Minhang District, Shanghai, China PC: 201100
Changzhou Foreign Trade Corp

Contact:+86-519-86623222

Address:29F/D, 99 Yanling West Road, Changzhou, Jiangsu, China

Relevant to this article

Structure- and reactivity-based development of covalent inhibitors of the activating and gatekeeper mutant forms of the epidermal growth factor receptor (EGFR)

Doi:10.1021/jm400822z
(2013)
Doi:10.1021/jo01375a002
(1954)
New silver(I)-monophosphine complex derived from chiral Ar-BINMOL: Synthesis and catalytic activity in asymmetric vinylogous Mannich reaction

Doi:10.1016/j.tet.2013.07.105
(2013)
Aromatic chlorination with thionyl chloride. Applications in the synthesis of chlorinated isoflavones

Doi:10.1080/10426500701509485
(2007)
Rational Synthesis of Trans-Substituted Porphyrin Building Blocks Containing One Sulfur or Oxygen Atom in Place of Nitrogen at a Designated Site

Doi:10.1021/jo9909305
(1999)
Novel Syntheses of Decacyclene by Deoxygenating Cyclotrimerisation of Acenaphthenequinone with Zero-valent Titanium or Phosphorus Pentasulfide

Doi:10.1055/s-1997-3209
(1997)

Article Doi