A simple and general method for the asymmetric synthesis of α-aminophosphonic acids

DOI: 10.1016/S0040-4039(00)60023-0

Source and publish data:

Tetrahedron Letters p. 6127 - 6130 (1992)

Update date:2022-08-02

Topics: Asymmetric synthesis Column chromatography Yield NMR spectroscopy Nucleophile Electrophile Enantioselectivity Deprotonation Recrystallization Hydrolysis HPLC (high-performance liquid chromatography) Protecting group Workup Chiral Resolution Chiral Catalyst Reaction Optimization Stoichiometric Control Phosphonate α-aminophosphonic acids

Authors:

Maury Maury

Royer Royer

Husson Husson

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Article abstract of DOI:10.1016/S0040-4039(00)60023-0

A simple and general method for the asymmetric synthesis of α-aminophosphonic acids is described. A chiral phosphonate prepared in one step from R-(-)-phenylglycinol was alkylated with good diastereoselectivity using different electrophiles.

Full text of DOI:10.1016/S0040-4039(00)60023-0

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Product name:[2-Phenyl-1-((R)-4-phenyl-oxazolidin-3-yl)-ethyl]-phosphonic acid dimethyl ester

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