Investigations concerning the benzylation of tetrahydroisoquinolines with benzaldehyde and substituted benzaldehyde (Rugheimer-Burrows-reaction)

DOI: 10.1002/ardp.19923251010

Source and publish data:

Archiv der Pharmazie p. 671 - 677 (1992)

Update date:2022-08-03

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Authors:

Dannhardt

Roelcke Roelcke

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Article abstract of DOI:10.1002/ardp.19923251010

The condensation of piperidine and tetrahydroisoquinoline derivatives with benzaldehyde leading to the corresponding benzylated aromatic systems is a multistep reaction for which different mechanisms are discussed. Isolation and characterization of the following intermediates and side products are helpful to explain parts of the sequence.

Full text of DOI:10.1002/ardp.19923251010

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