Synthesis and antitumor activity of novel 6-alkyl-6-demethylmitomycins

DOI: 10.1021/jm00038a009

Source and publish data:

Journal of Medicinal Chemistry p. 1805 - 1809 (1994)

Update date:2022-08-05

Topics:

Authors:

Arai Arai

Kanda Kanda

Ashizawa

Morimoto

Gomi Gomi

Kono Kono

Kasai Kasai

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Article abstract of DOI:10.1021/jm00038a009

A series of 6-alkyl-6-demethylmitomycins (1-5) was synthesized and evaluated for anticellular and antitumor activities. These novel compounds were prepared by Michael addition of various carbanion species to 6-demethyl- 7,7-(ethylenedioxy)-6,7-dihydro-6-m

Full text of DOI:10.1021/jm00038a009

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Product name:6-demethyl-6-ethylmitomycin C

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