Copper on iron promoted one-pot synthesis of β-aminoenones and 3,5-disubstituted pyrazoles

Article abstract of DOI:10.1016/j.tet.2013.08.047

The reaction of hydroximoyl chlorides with acetylenes in the presence of a copper on iron bimetallic system leads to β-aminoenones via reductive ring opening of isoxazole intermediates. The valuable β-aminoenone building blocks can be isolated or transformed into pyrazoles with the addition of hydrazine in a straightforward one-pot procedure.