Inhibitory effect of acylphloroglucinol derivatives on the replication of vesicular stomatitis virus.

Article abstract of DOI:10.1271/bbb.56.1769

The antiviral activity of natural phloroglucinols and of synthesized mono- and diacylphloroglucinols, and 2,6-diacyl-4,4-dialkylcyclohexa-1,3,5-triones was investigated. A correlation between the acyl chain length and inhibitory activity against vesicular stomatitis virus (VSV) was observed. Potent antiviral activity was found in di-isovalerylphoroglucinol. 2,6-Diacyl-4,4-dialkylcyclohexa-1,3,5-triones inhibited replication of the virus with low cytotoxicity.

Full text of DOI:10.1271/bbb.56.1769

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Inhibitory Effect of Acylphloroglucinol Derivatives on
the Replication of Vesicular Stomatitis Virus
Kazuhiro Chibaa, Takako Takakuwaa, Masahiro Tadaa & Takao Yoshiiab
a Laboratory of Bio-organic Chemistry, Tokyo University of Agriculture and Technology,
Fuchu, Tokyo 183, Japan
b Central Virus Diagnostic Laboratory, National Institute of Health, 4–7–1 Gakuen,
Musashimurayama, Tokyo 190–12, Japan
Published online: 12 Jun 2014.
To cite this article: Kazuhiro Chiba, Takako Takakuwa, Masahiro Tada & Takao Yoshii (1992) Inhibitory Effect of
Acylphloroglucinol Derivatives on the Replication of Vesicular Stomatitis Virus, Bioscience, Biotechnology, and
Biochemistry, 56:11, 1769-1772, DOI: 10.1271/bbb.56.1769
To link to this article: http://dx.doi.org/10.1271/bbb.56.1769
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