Efficient Syntheses of Acromelic Acids B and E, Which Are Potent Neuroexcitatory Amino Acids

DOI: 10.1016/S0040-4039(00)60580-4

Source and publish data:

Tetrahedron Letters p. 331 - 334 (1993)

Update date:2022-08-04

Topics:

Authors:

Horikawa, Manabu

Hashimoto, Kimiko

Shirahama, Haruhisa

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Article abstract of DOI:10.1016/S0040-4039(00)60580-4

(-)-Acromelic acid B (2) was synthesized from 2-cyano-3-(2-hydroxyethyl)pyridine (4) in 21percent overall yield.Acromelic acid E (3) was also prepared on the way of above synthesis.

Full text of DOI:10.1016/S0040-4039(00)60580-4

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Product name:2-{(S)-3-[2-(2-Formyl-pyridin-3-yl)-ethyl]-2-oxo-oxazolidin-4-ylmethylene}-malonic acid di-tert-butyl ester

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