Novel 1-phenylpiperazine and 4-phenylpiperidine derivatives as high-affinity σ ligands

Article abstract of DOI:10.1021/jm00116a003

σ receptors may represent an exciting new approach for the development of novel psychotherapeutic agents. Unfortunately, many of the commonly used σ ligands lack selectivity (e.g., many bind at phencyclidine or dopamine receptors) or suffer from other ser