Benzodioxoles: Novel cannabinoid-1 receptor inverse agonists for the treatment of obesity

DOI: 10.1021/jm701487t

Source and publish data:

Journal of Medicinal Chemistry p. 2115 - 2127 (2008)

Update date:2022-08-03

Topics:

Authors:

Alig, Leo

Alsenz, Jochem

Andjelkovic, Mirjana

Bendels, Stefanie

Bénardeau, Agnès

Bleicher, Konrad

Bourson, Anne

David-Pierson, Pascale

Guba, Wolfgang

Hildbrand, Stefan

Kube, Dagmar

Lübbers, Thomas

Mayweg, Alexander V.

Narquizian, Robert

Neidhart, Werner

Nettekoven, Matthias

Plancher, Jean-Marc

Rocha, Cynthia

Rogers-Evans, Mark

R?ver, Stephan

Schneider, Gisbert

Taylor, Sven

Waldmeier, Pius

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Article abstract of DOI:10.1021/jm701487t

The application of the evolutionary fragment-based de novo design tool TOPology Assigning System (TOPAS), starting from a known CB1R (CB-1 receptor) ligand, followed by further refinement principles, including pharmacophore compliance, chemical tractabili

Full text of DOI:10.1021/jm701487t

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