The Conversion of Secondary into Tertiary Amides Using Benzotriazole Methodology

DOI: 10.1021/jo00060a025

Source and publish data:

Journal of Organic Chemistry p. 2086 - 2093 (1993)

Update date:2022-07-29

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Authors:

Katritzky, Alan R.

Yao, Guowei

Lan, Xiangfu

Zhao, Xiaohong

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Article abstract of DOI:10.1021/jo00060a025

N-Alkyl-N-<1-(benzotriazol-1-yl)alkyl>amides, easily prepared from benzotriazole, an aldehyde, and a secondary amide, react readily with organozinc reagents to give tertiary amides in moderate to good yields.They are also reduced by LiAlH4 to afford tertiary amines.

Full text of DOI:10.1021/jo00060a025

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