Stereocontrolled Construction of Substituted Pyrrolidines based on Intramolecular Protodesilylation Reaction. Enantiospecific Synthesis of (-)-Kainic Acid and (+)-Allokainic Acid from L-Serine

DOI: 10.1039/c39930000125

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Journal of the Chemical Society. Chemical communications p. 125 - 127 (1993)

Update date:2022-08-03

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Authors:

Hatakeyama, Susumi

Sugawara, Kazutoshi

Takano, Seiichi

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Article abstract of DOI:10.1039/c39930000125

Novel stereocontrolled enantiospecific syntheses of (-)-kainic acid and (+)-allokainic acid have been achieved starting from L-serine via two modes of C-2 and C-3 side chain-directed intramolecular protodesilylations of 4-(trimethylsilylmethyl)ethylidenepyrrolidines.

Full text of DOI:10.1039/c39930000125

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