Synthesis and evaluation of new elastase inhibitors. I. 1,1-Dioxocephem-4-thiolesters

DOI: 10.1016/0223-5234(92)90019-W

Source and publish data:

European Journal of Medicinal Chemistry p. 875 - 890 (1992)

Update date:2022-08-03

Topics:

Authors:

Alpegiani

Baici Baici

Bissolino

Carminati

Cassinelli

Del Nero

Franceschi

Orezzi Orezzi

Perrone Perrone

Rizzo Rizzo

Sacchi Sacchi

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Article abstract of DOI:10.1016/0223-5234(92)90019-W

Several 7α-chloro and 7α-methoxy cephalosporin thiolester sulphones variously substituted at the C-3' position were synthesized from 7-amino-3-deacetoxycephalosporanic acid (7-ADCA). The compounds are time-dependent inhibitors of human leukocyte elastase

Full text of DOI:10.1016/0223-5234(92)90019-W

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Product name:benzyl 3-acetoxymethyl-7α-chloro-3-cephem-4-carboxylate 1,1-dioxide

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