Synthesis and evaluation of new elastase inhibitors. I. 1,1-Dioxocephem-4-thiolesters

Article abstract of DOI:10.1016/0223-5234(92)90019-W

Several 7α-chloro and 7α-methoxy cephalosporin thiolester sulphones variously substituted at the C-3' position were synthesized from 7-amino-3-deacetoxycephalosporanic acid (7-ADCA). The compounds are time-dependent inhibitors of human leukocyte elastase