Bioorganic and Medicinal Chemistry p. 255 - 261 (1996)
Update date:2022-08-03
Topics:
Wyman, Paul A.
Gaster, Laramie M.
King, Frank D.
Sutton, Jonathon M.
Ellis, Elizabeth S.
Wardle, Kay A.
Young, Timothy J.
The synthesis of a series of azabicyclic indole esters is described and their potency reported as 5-HT4 receptor antagonists. Optimization of the most potent compound (19) by preparing the corresponding oxazino[3,2-a]indole ester afforded 34, which had a pIC50 of 9.5 in the guinea pig distal colon longitudinal muscle myenteric plexus preparation.
View MoreHefei Highzone Fine Chemical S&T CO.,LTD
Contact:86-0551-63663560
Address:room 1801 NO. 24 Shuguang RD.
Shanghai Sinofluoro Scientific Co., Ltd
Contact:+86-21-64279360
Address:Room 1006,Building 3,#58 East Xinjian Road, Shanghai ,201100,China,
Shenzhen Hongyuan Import & Export Co., Ltd.
Contact:0755-26407171
Address:Shenzhen Hongyuan Chemical New Materials Technology Co., Ltd.
Tianjin Emulsion Science&Technology Development Co.,Ltd
Contact:13901380442
Address:Vake Garden New Town New Yi Bai Road Beichen District Tianjin,China
Yurui(Shanghai)Chemical Co.,Ltd
Contact:0086 21-50456736
Address:No.3188 Xiupu Road,Shanghai
Doi:10.1246/cl.130370
(2013)Doi:10.1002/anie.200501635
(2005)Doi:10.1055/s-1993-25858
(1993)Doi:10.1016/S0040-4020(01)96301-X
(1968)Doi:10.1039/b504602e
(2005)Doi:10.1021/ja01200a013
(1947)
