A general method for the preparation of 5-trifluoromethylated oxazoles from α-amino acids

DOI: 10.1248/cpb.46.749

Source and publish data:

Chemical and Pharmaceutical Bulletin p. 749 - 756 (1998)

Update date:2022-07-29

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Authors:

Kawase, Masami

Miyamae, Hiroshi

Kurihara, Teruo

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Article abstract of DOI:10.1248/cpb.46.749

The reactions of N-acyl-N-benzyl-α-amino acids (1) or N-acylprolines (5) with trifluoroacetic anhydride in the presence of pyridine afford 5- trifluoromethyloxazoles (2 or 7) in good yields. The reaction could proceed through the transient formation of me

Full text of DOI:10.1248/cpb.46.749

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