Metelation of diazines VIII metalation of 4-chloropyrimidine derivatives new synthesis of trimethoprim

DOI: 10.1016/0040-4039(93)85019-S

Source and publish data:

Tetrahedron Letters p. 1605 - 1608 (1993)

Update date:2022-08-02

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Authors:

Ple Ple

Turck Turck

Martin Martin

Barbey Barbey

Queguiner

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Article abstract of DOI:10.1016/0040-4039(93)85019-S

A new synthesis of trimethoprim is described, metalation of a pyrimidine has been used in the key step. An exceptional regioselectivity in the metalation of pyrimidine derivatives has been highlighted.

Full text of DOI:10.1016/0040-4039(93)85019-S

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