Synthesis of (-)-Pinidine via Asymmetric, Electrophilic Enolate Hydroxyamination/Nitrone Reduction

DOI: 10.1002/hlca.19930760218

Source and publish data:

Helvetica Chimica Acta p. 957 - 962 (1993)

Update date:2022-08-04

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Authors:

Oppolzer, Wolfgang

Merifield, Eric

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Article abstract of DOI:10.1002/hlca.19930760218

Enantiomerically pure (-)-pinidine (1) has been synthesized in 18.5 percent overall yield by a nine-step sequence starting from keto-ester 2.The key step 5 -> 6 involves an asymmetric, electrophilic enolate hydroxyamination.Diastereoselective hydrogenatio

Full text of DOI:10.1002/hlca.19930760218

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