A diastereoselective synthesis of pseudo-C2 -symmetric 1,3-diamino-2-propanols as core units in HIV protease inhibitors

Article abstract of DOI:10.1016/S0040-4020(01)80342-2

Inhibitors of HIV-1 protease are effective against the proliferation of HIV-1 infection in vitro. Based on the inherent symmetry of the protease homodimer, C₂-symmetric and pseudo-C₂-symmetric inhibitors have been designed, synthesiz