Synthesis of mono- and sesquiterpenoids; XXII. Synthesis of (+)-pinthunamide, a sesquiterpene metabolite of a fungus, Ampulliferina sp.

Article abstract of DOI:10.1055/s-1993-25873

Pinthunamide (1), a sesquiterpene metabolite produced by a fungus Ampliferina sp., was synthesized by starting from (1R,4S,6S)-6-hydroxy-1-methylbicyclo[2,2]octan-2-one (4), which could readily be prepared by yeast reduction of the corresponding β-diketone 5.