Tryptophan-containing 1,5-tetrazole dipeptide analogs: Synthesis of Trpψ [CN4]Nle as a cis amide bond surrogate

DOI: 10.1016/S0040-4039(00)60771-2

Source and publish data:

Tetrahedron Letters p. 1757 - 1760 (1993)

Update date:2022-08-02

Topics:

Authors:

Boteju, Lakmal W.

Hruby, Victor J.

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Article abstract of DOI:10.1016/S0040-4039(00)60771-2

The 1,5-disubstituted tetrazole dipeptide analog Z-Trp(NⁱⁿZ)ψ[CN₄]Nle-OBzl was synthesized in good yield and high optical purity using a modified procedure of Zabrocki et al. This dipeptide analog can be selectively deprotected at either the N or the C terminal for further incorporation into peptides.

Full text of DOI:10.1016/S0040-4039(00)60771-2

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