Tryptophan-containing 1,5-tetrazole dipeptide analogs: Synthesis of Trpψ [CN4]Nle as a cis amide bond surrogate

Article abstract of DOI:10.1016/S0040-4039(00)60771-2

The 1,5-disubstituted tetrazole dipeptide analog Z-Trp(NⁱⁿZ)ψ[CN₄]Nle-OBzl was synthesized in good yield and high optical purity using a modified procedure of Zabrocki et al. This dipeptide analog can be selectively deprotected at either the N or the C terminal for further incorporation into peptides.