SYNTHESIS OF BILE ACID - DRUG CONJUGATES: POTENTIAL DRUG - SHUTTLES FOR LIVER SPECIFIC TARGETING

DOI: 10.1016/0040-4039(93)89021-H

Source and publish data:

Tetrahedron Letters p. 819 - 822 (1993)

Update date:2022-07-29

Topics:

Authors:

Wess, G.

Kramer, W.

Schubert, G.

Enhsen, A.

Baringhaus, K.-H.

et al. et al.

Read Full Text PDF DownLoad Join now for total 90,000,000 free articles

Article abstract of DOI:10.1016/0040-4039(93)89021-H

Cholic acid (1) has been coupled via ω-aminoalkoxy spacer at C-3 to chlorambucil (3), HR 780 (4) and oxaproline peptide (5).Drug conjugates 9, 11, 18 exhibit strong affinity to specific bile acid transport systems.

Full text of DOI:10.1016/0040-4039(93)89021-H

Products guided by the article

Product name:(S)-2-[(S)-2-(9H-Fluoren-9-ylmethoxycarbonylamino)-3-phenyl-propionyl]-isoxazolidine-3-carboxylic acid

Cas No:149079-62-9

R&D Labs maybe for 149079-62-9

hangzhou verychem science and technology co.ltd

website:http://www.verypharm.com

Contact:+86-571-88162785; 88162786

Address:F1502, 753 Shenhua road, Hangzhou, China
Exploiter Molybdenum Co.,Ltd

Contact:86-379-63338609

Address:Jiudian Village,Deting Town,Song County,Luoyang
Hangzhou Ledun Technology Co.,Ltd.

Contact:86-571-18767088918

Address:No.6 street,XiaSha,Hangzhou,China.
Shanghai Dynamic Industrial Co.,Ltd.

website:http://www.shdynamic.com

Contact:86-021 3392 6680

Address:Room 805 Information Tower, No.1403 Minsheng Road, Pudong New Area, Shanghai 200135, P. R. China
Reliable Pharma Technology (Shanghai) Co., Ltd.

Contact:0086-21-67676847-8008

Address:Lane 1500, No.68, Xinfei Road, Songjiang District, Shanghai, 201611, P.R.China.

Relevant to this article

FACILE PRODUCTION AND CYCLIZATIONS OF AMIDYL RADICALS

Doi:10.1016/S0040-4039(00)74480-7
(1991)
Raman-spectroscopy of oligomeric SiO species isolated in solid methane

Doi:10.1063/1.480123
(1999)
Alkali carbonate effects on N-(2-hydroxyethyl)urea cyclization: Application to a 2-imidazolidinone scale-up

Doi:10.1002/jhet.1648
(2013)
Doi:10.1139/v67-233
(1967)
Potent quinoxaline-based inhibitors of PDGF receptor tyrosine kinase activity. Part 1: SAR exploration and effective bioisosteric replacement of a phenyl substituent

Doi:10.1016/S0960-894X(03)00654-1
(2003)
Cyclic GMP Phosphodiesterase Inhibitors. 2. Requirement of 6-Substitution of Quinazoline Derivatives for Potent and Selective Inhibitory Activity

Doi:10.1021/jm00039a024
(1994)

Article Doi