SYNTHESIS OF BILE ACID - DRUG CONJUGATES: POTENTIAL DRUG - SHUTTLES FOR LIVER SPECIFIC TARGETING

DOI: 10.1016/0040-4039(93)89021-H

Source and publish data:

Tetrahedron Letters p. 819 - 822 (1993)

Update date:2022-07-29

Topics:

Authors:

Wess, G.

Kramer, W.

Schubert, G.

Enhsen, A.

Baringhaus, K.-H.

et al. et al.

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Article abstract of DOI:10.1016/0040-4039(93)89021-H

Cholic acid (1) has been coupled via ω-aminoalkoxy spacer at C-3 to chlorambucil (3), HR 780 (4) and oxaproline peptide (5).Drug conjugates 9, 11, 18 exhibit strong affinity to specific bile acid transport systems.

Full text of DOI:10.1016/0040-4039(93)89021-H

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