Adenosine deaminase inhibitors: Synthesis and structure-activity relationships of imidazole analogues of erythro-9-(2-hydroxy-3-nonyl)adenine

DOI: 10.1021/jm00107a044

Source and publish data:

Journal of Medicinal Chemistry p. 1187 - 1192 (1991)

Update date:2022-09-26

Topics:

Authors:

Cristalli

Eleuteri

Franchetti

Grifantini

Vittori Vittori

Lupidi Lupidi

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Article abstract of DOI:10.1021/jm00107a044

A series of erythro-1-(2-hydroxy-3-nonyl)imidazole derivatives have been synthesized and evaluated for adenosine deaminase (ADA) inhibitory activity, in order to introduce simplifications in the ADA inhibitors erythro-9-(2-hydroxy-3-nonyl)adenine (EHNA, 1

Full text of DOI:10.1021/jm00107a044

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