Optimizing the structure of 4-dialkylamino-α,α-diarylprolinol ethers as catalysts for the enantioselective cyclopropanation of α,β-unsaturated aldehydes in water

Article abstract of DOI:10.1002/cctc.201300097

We optimized the structure of a new family of chiral diarylprolinol-type organocatalysts with improved performances in conjugate addition reactions performed in water and proceeding under the iminium activation manifold. The principles behind the catalyst