Rational design, synthesis, and crystallographic analysis of a hydroxyethylene-based HIV-1 protease inhibitor containing a heterocyclic P1'-P2' amide bond isostere

DOI: 10.1021/jm00045a015

Source and publish data:

Journal of Medicinal Chemistry p. 3100 - 3107 (1994)

Update date:2022-09-26

Topics:

Authors:

Thompson

Murthy Murthy

Zhao Zhao

Winborne

Green Green

Fisher Fisher

DesJarlais

Tomaszek Jr.

Meek Meek

Gleason Gleason

Abdel-Meguid

Read Full Text PDF DownLoad Join now for total 90,000,000 free articles

Article abstract of DOI:10.1021/jm00045a015

The rational design and synthesis of a highly potent inhibitor of HIV-1 protease have been accomplished. The inhibitor, SB 206343, is based on a model derived from the structure of the MVT-101/HIV-1 protease complex and contains a 4(5)-acylimidazole ring

Full text of DOI:10.1021/jm00045a015

Products guided by the article

Product name:(2R,4S,5S)-2-benzyl-5-<(tert-butoxycarbonyl)amino>-4-(tert-butyldimethylsiloxy)-N-(isoxazol-4-yl)-6-phenylhexanamide

Cas No:149976-34-1

R&D Labs maybe for 149976-34-1

Yixing Zhenfen Medical Chemical Co.Ltd

Contact:86-510-87552708

Address:Fenshui ,Yixing city,Jiangsu
Sarchem Laboratories, Inc.

Contact:732.938.2777

Address:5012 Industrial Road Farmingdale, NJ 07727
Zhonghao (dalian) Research and Design Institute of Chemical Industry Co., Ltd

Contact:+86 411 84674606

Address:201, Huangpu Road , Shahekou District, Dalian ,116023-China
Engineering Research Center of Pesticide, Heilongjiang Province

Contact:+86-451-86609001

Address:No.74 of Xuefu Road, Nangang District,
Chiral Quest (Suzhou) Company Ltd

website:http://www.chiralquest.com

Contact:+86-0512-62956066

Address:B1/9, 218 Xinghu Street, Suzhou Industrial Park

Relevant to this article

New magnetic nanocomposites of ZrO₂-Al₂O ₃-Fe₃O₄ as green solid acid catalysts in organic reactions

Doi:10.1039/c3cy00572k
(2014)
Directing the biological activities of heparan sulfate oligosaccharides using a chemoenzymatic approach

Doi:10.1093/glycob/cwr109
(2012)
Simple bipolar host materials incorporating CN group for highly efficient blue electrophosphorescence with slow efficiency roll-off

Doi:10.1039/c3tc31893a
(2013)
Synthesis of a dicyano abietane, a key intermediate for the anti-inflammatory agent TBE-31

Doi:10.1021/ol403289y
(2014)
Functionalization of Penicillins Via Iodine Atom Transfer Chemistry

Doi:10.1016/S0040-4020(01)89907-5
(1993)
Torsional Strain as Determinant for the Polymerizability of Cyclic Olefins: The Ring-Opening Metathesis Polymerization of 1,1,2,2-Tetramethyl-1,2-disilacyclopent-3-ene

Doi:10.1021/ja00075a069
(1993)

Article Doi