Rational design, synthesis, and crystallographic analysis of a hydroxyethylene-based HIV-1 protease inhibitor containing a heterocyclic P1'-P2' amide bond isostere

DOI: 10.1021/jm00045a015

Source and publish data:

Journal of Medicinal Chemistry p. 3100 - 3107 (1994)

Update date:2022-09-26

Topics:

Authors:

Thompson

Murthy Murthy

Zhao Zhao

Winborne

Green Green

Fisher Fisher

DesJarlais

Tomaszek Jr.

Meek Meek

Gleason Gleason

Abdel-Meguid

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Article abstract of DOI:10.1021/jm00045a015

The rational design and synthesis of a highly potent inhibitor of HIV-1 protease have been accomplished. The inhibitor, SB 206343, is based on a model derived from the structure of the MVT-101/HIV-1 protease complex and contains a 4(5)-acylimidazole ring

Full text of DOI:10.1021/jm00045a015

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