Rational design, synthesis, and crystallographic analysis of a hydroxyethylene-based HIV-1 protease inhibitor containing a heterocyclic P1'-P2' amide bond isostere

DOI: 10.1021/jm00045a015

Source and publish data:

Journal of Medicinal Chemistry p. 3100 - 3107 (1994)

Update date:2022-09-26

Topics:

Authors:

Thompson

Murthy Murthy

Zhao Zhao

Winborne

Green Green

Fisher Fisher

DesJarlais

Tomaszek Jr.

Meek Meek

Gleason Gleason

Abdel-Meguid

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Article abstract of DOI:10.1021/jm00045a015

The rational design and synthesis of a highly potent inhibitor of HIV-1 protease have been accomplished. The inhibitor, SB 206343, is based on a model derived from the structure of the MVT-101/HIV-1 protease complex and contains a 4(5)-acylimidazole ring

Full text of DOI:10.1021/jm00045a015

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Article Doi

Rational design, synthesis, and crystallographic analysis of a hydroxyethylene-based HIV-1 protease inhibitor containing a heterocyclic P1'-P2' amide bond isostere

DOI: 10.1021/jm00045a015

Source and publish data:

Authors:

Article abstract of DOI:10.1021/jm00045a015

Full text of DOI:10.1021/jm00045a015

Products guided by the article

R&D Labs maybe for 149976-34-1

Relevant to this article

New magnetic nanocomposites of ZrO2-Al2O 3-Fe3O4 as green solid acid catalysts in organic reactions

Directing the biological activities of heparan sulfate oligosaccharides using a chemoenzymatic approach

Simple bipolar host materials incorporating CN group for highly efficient blue electrophosphorescence with slow efficiency roll-off

Synthesis of a dicyano abietane, a key intermediate for the anti-inflammatory agent TBE-31

Functionalization of Penicillins Via Iodine Atom Transfer Chemistry

Torsional Strain as Determinant for the Polymerizability of Cyclic Olefins: The Ring-Opening Metathesis Polymerization of 1,1,2,2-Tetramethyl-1,2-disilacyclopent-3-ene

New magnetic nanocomposites of ZrO₂-Al₂O ₃-Fe₃O₄ as green solid acid catalysts in organic reactions