Studies on Neurokinin Antagonists. 3. Design and Structure-Activity Relationships of New Branched Tripeptides Nα-(Substituted L-aspartyl, L-ornithyl, or L-lysyl)-N-methyl-N-(phenylmethyl)-L-phenylalaninamides as Substance P Antagonists

DOI: 10.1021/jm00068a003

Source and publish data:

Journal of Medicinal Chemistry p. 2266 - 2278 (1993)

Update date:2022-07-30

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Authors:

Hagiwara, Daijiro

Miyake, Hiroshi

Murano, Kenji

Morimoto, Hiroshi

Murai, Masako

et al. et al.

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Article abstract of DOI:10.1021/jm00068a003

As an extension of our study on discovering a novel substance P (SP) antagonist, we designed new branched tripeptides containing L-aspartic acid, (2 and 5), L-ornithine (3 and 6), and L-lysine (4 and 7) by reconstructing the structure of the previously re

Full text of DOI:10.1021/jm00068a003

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