Studies on Neurokinin Antagonists. 3. Design and Structure-Activity Relationships of New Branched Tripeptides Nα-(Substituted L-aspartyl, L-ornithyl, or L-lysyl)-N-methyl-N-(phenylmethyl)-L-phenylalaninamides as Substance P Antagonists

DOI: 10.1021/jm00068a003

Source and publish data:

Journal of Medicinal Chemistry p. 2266 - 2278 (1993)

Update date:2022-07-30

Topics:

Authors:

Hagiwara, Daijiro

Miyake, Hiroshi

Murano, Kenji

Morimoto, Hiroshi

Murai, Masako

et al. et al.

Read Full Text PDF DownLoad Join now for total 90,000,000 free articles

Article abstract of DOI:10.1021/jm00068a003

As an extension of our study on discovering a novel substance P (SP) antagonist, we designed new branched tripeptides containing L-aspartic acid, (2 and 5), L-ornithine (3 and 6), and L-lysine (4 and 7) by reconstructing the structure of the previously re

Full text of DOI:10.1021/jm00068a003

Products guided by the article

Product name:Boc-D-Lys(Z)-Phe-NMeBzl

Cas No:150113-36-3

R&D Labs maybe for 150113-36-3

CHANGZHOU HANGYU PHARMACEUTICAL TECHNOLOGY CO., LTD

website:http://www.czyys.com

Contact:0086-519-88802789

Address:No.300,Yanling Middle Road, Changzhou, Jiangsu, China
SHANGHAI T&W PHARMACEUTICAL CO., LTD.

website:http://www.trustwe.com

Contact:+86-21-61551413

Address:601, No. 1, 2277 Nong, Zu Chongzhi Road, Zhangjiang Hightech. Park, Pudong
AUSHUN PHARMACEUTICAL TECHNOLOGY CO,.LTD

Contact:+86-25-86883560 15951806178

Address:14 Dayingbi, Zhujiang Rd. East, Nanjing, Jiangsu, China.
Suzhou Howsine Biological Technology Co.,Ltd(expird)

website:http://www.howsine.com

Contact:86-512-67262751

Address:No 3,Weihua Road ,Suzhou Industrial Park ,Jiangsu ,China.
Xian Changyue Biological Technology Co., Ltd.

website:https://www.xachangyue.com/

Contact:+86-029-88211911

Address:Keji Road NO.70

Relevant to this article

A series of penicillin derived C2-symmetric inhibitors of HIV-1 proteinase: synthesis, mode of interaction, and structure-activity relationships.

Doi:10.1021/jm00073a011
(1993)
Graphene oxide: An efficient and reusable carbocatalyst for aza-Michael addition of amines to activated alkenes

Doi:10.1039/c1cc15230k
(2011)
Direct detection of S-palmitoylation by mass spectrometry

Doi:10.1021/ac402850s
(2013)
Borole derivatives X. Syntheses of (η⁵-borole)metal complexes via borole ammonia adducts. Complexes of the chromium group metals and the crystal and molecular structures of tetracarbonyl <η⁵-(1-phenylborole)>chromium and its molybden

Doi:10.1016/0022-328X(87)87155-3
(1987)
Oxoammonium Salts. 5. A New Synthesis of Hindered Piperidines Leading to Unsymmetrical TEMPO-Type Nitroxides. Synthesis and Enantioselective Oxidations with Chiral Nitroxides and Chiral Oxoammonium Salts

Doi:10.1021/jo00070a018
(1993)
Doi:10.1021/jo01267a069
(1968)

Article Doi