Preparation of Spirocyclic Cyclopropyl Ketones through Condensation of Epoxides with β-Keto Phosphonates

DOI: 10.1021/jo00069a018

Source and publish data:

Journal of Organic Chemistry p. 4584 - 4588 (1993)

Update date:2022-08-03

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Authors:

Jacks, Thomas E.

Nibbe, Heidi

Wiemer, David F.

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Article abstract of DOI:10.1021/jo00069a018

The β-keto phosphonate derivatives of several cyclic ketones have been shown to undergo condensation with epoxides upon treatment with base, affording spirocyclic cyclopropyl ketones.Moderate to reasonable yields were obtained under sealed tube conditions

Full text of DOI:10.1021/jo00069a018

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