Preparation of Spirocyclic Cyclopropyl Ketones through Condensation of Epoxides with β-Keto Phosphonates

DOI: 10.1021/jo00069a018

Source and publish data:

Journal of Organic Chemistry p. 4584 - 4588 (1993)

Update date:2022-08-03

Topics:

Authors:

Jacks, Thomas E.

Nibbe, Heidi

Wiemer, David F.

Read Full Text PDF DownLoad Join now for total 90,000,000 free articles

Article abstract of DOI:10.1021/jo00069a018

The β-keto phosphonate derivatives of several cyclic ketones have been shown to undergo condensation with epoxides upon treatment with base, affording spirocyclic cyclopropyl ketones.Moderate to reasonable yields were obtained under sealed tube conditions

Full text of DOI:10.1021/jo00069a018

Products guided by the article

Product name:1-Phenylspiro<2.5>octan-4-one

Cas No:150128-09-9

R&D Labs maybe for 150128-09-9

SHIJIAZHUANG CHENSHI IMPORT AND EXPORT CO.,LTD

Contact:+86-311-89871056

Address:RM2017 BUILDING CTIANSHAN GALAXY PLAZA,NO168 CHANGJIANG ROAD,GAOXIN DISTRICT,SHIJIAZHUANG CITY, HEBEI,CHINA
wuxi huabin bio-tech Co.,Ltd(expird)

Contact:86-0510-85133006

Address:hubin road NO157
Tianjin SPHINX SCIENTIFIC LAB.

Contact:+86-022-66211289

Address:Tianda high-tech Park. No.80,the 4th Avenue
Shandong united-rising pharmaceutical cooperation.,ltd.

Contact:008653187965009

Address:171No., Jing5 Road, Shizhong District, Jinan, China
Cerametek Materials（ShenZhen）Co., Ltd.

Contact:+86-755-2324.2554

Address:A3-#9, YongChuan Street, Suite 501

Relevant to this article

AURANTIAMIDES: A NEW CLASS OF MODIFIED DIPEPTIDES FROM PIPER AURANTIACUM

Doi:10.1016/0031-9422(81)80116-1
(1981)
Sequential diastereoselective free radical reactions: Synthesis of an advanced olivomycin A C-D disaccharide

Doi:10.1016/S0040-4039(00)79162-3
(1993)
Synthesis and spectral characterization of some novel thiazolyl-pyrazoline derivatives containing 1,2,3-triazole moiety

Doi:10.1080/10426507.2010.494647
(2011)
Cellulose sulfuric acid as a bio-supported and efficient solid acid catalyst for synthesis of pyrazoles in aqueous medium

Doi:10.1039/c4ra11440j
(2014)
The synthesis of Plicatin B via the Heck reaction

Doi:10.1016/S0040-4039(00)73632-X
(1993)
Practical large scale synthesis of tert-butyl (3R,5S)-6-hydroxy-3,5-O-isopropylidene-3,5-dihydroxyhexanoate: Essential building block for HMG-CoA reductase inhibitors

Doi:10.1055/s-1995-4028
(1995)

Article Doi