Practical large scale synthesis of tert-butyl (3R,5S)-6-hydroxy-3,5-O-isopropylidene-3,5-dihydroxyhexanoate: Essential building block for HMG-CoA reductase inhibitors

DOI: 10.1055/s-1995-4028

Source and publish data:

Synthesis p. 1014 - 1018 (1995)

Update date:2022-08-03

Topics:

Authors:

Beck Beck

Jendralla

Kesseler

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Article abstract of DOI:10.1055/s-1995-4028

Title compound 7 (96% ee, > 98% de) is synthesized enantioselectively in six steps (36% overall yield) from the commercial β-keto ester 8 on a multi-kg scale.

Full text of DOI:10.1055/s-1995-4028

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