Influence of lipophilicity on the biological activity of cyclic pseudopeptide NK-2 receptor antagonists

DOI: 10.1021/jm00047a020

Source and publish data:

Journal of Medicinal Chemistry p. 3630 - 3638 (1994)

Update date:2022-08-04

Topics:

Authors:

Quartara

Fabbri Fabbri

Ricci Ricci

Patacchini

Pestellini

Maggi Maggi

Pavone Pavone

Giachetti

Arcamone

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Article abstract of DOI:10.1021/jm00047a020

A series of cyclic pseudopeptides of the formula cyclo(LeuΨ[CH₂NH]Xaa- Gln-Trp-Phe-βAla), where Xaa represents the residue of an α-amino acid, has been synthesized in order to establish the role of the Xaa side chain for tachykinin NK-2 recepto

Full text of DOI:10.1021/jm00047a020

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