Synthetic Analogues of Low-Molecular-Weight Acyl-polyamine Spider Toxins

Article abstract of DOI:10.1002/hlca.19930760304

Low-molecular-weight spider and wasp toxins are selective inhibitors of glutamate receptors of the central nervous system and consist of a polyamine backbone and one or several carboxylic acids and/or amino acids linked by a peptide-like bond.The syntheses of twelve analogues of spider and wasp toxins are described (10a-c, 15a-c, 20a-c, 25a-c) having the general structure of acyl, arylacyl, or heteroarylacyl -> DL-alanyl -> ω-aminoacyl -> N¹-spermidine, with variation in the acyl and the ω-aminoacyl part.