Tetrahedron p. 9743 - 9756 (1994)
Update date:2022-08-04
Topics:
Gundersen
Bakkestuen
Aasen
Overas
Rise
N-9 and N-7 benzylated 6-halopurines readily participate in palladium catalyzed cross coupling reactions with organotin and organozinc derivatives. In most instances the 6-chloropurines can be used. Organostannanes are excellent reagents for the introduction of alkenyl and aryl substituents, but organozinc compounds are the reagents of choice for the introduction of alkyl groups.
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