6-Halopurines in palladium-catalyzed coupling with organotin and organozinc reagents

Article abstract of DOI:10.1016/S0040-4020(01)85540-X

N-9 and N-7 benzylated 6-halopurines readily participate in palladium catalyzed cross coupling reactions with organotin and organozinc derivatives. In most instances the 6-chloropurines can be used. Organostannanes are excellent reagents for the introduction of alkenyl and aryl substituents, but organozinc compounds are the reagents of choice for the introduction of alkyl groups.