3-Substituted, 3-(4-pyridinylmethyl)-1,3-dihydro-1-phenyl-2H-indol-2-ones as acetylcholine release enhancers: Synthesis and SAR

DOI: 10.1021/jm00072a009

Source and publish data:

Journal of Medicinal Chemistry p. 2899 - 2907 (1993)

Update date:2022-08-05

Topics:

Authors:

Wilkerson

Kergaye Kergaye

Tam Tam

Read Full Text PDF DownLoad Join now for total 90,000,000 free articles

Article abstract of DOI:10.1021/jm00072a009

A series of 3-substituted, 3-(4-pyridinylmethyl)-1,3-dihydro-1-phenyl-2H- indol-2-ones was synthesized and found to enhance the stimulus-induced release of neurotransmitter acetylcholine (AcCh), and by doing so, might be useful in treating cognitive disor

Full text of DOI:10.1021/jm00072a009

Products guided by the article

Product name:2,3-dihydro-2-oxo-1-phenyl-3-(4-pyridinylmethyl)-1H-indole-3-butanoic acid ethyl ester

Cas No:150897-91-9

R&D Labs maybe for 150897-91-9

Sarchem Laboratories, Inc.

Contact:732.938.2777

Address:5012 Industrial Road Farmingdale, NJ 07727
Jiaxing Carry Bio-Chem Technology Co.,Ltd

website:http://www.carrybiotech.com

Contact:0573-82788958

Address:Add.Fl 3th, Pharm Vally,Kaichuang Rd, Xiuzhou District, Jiaxing, Zhejiang,314031,China
Shanghai Massive Chemical Technology Co., Ltd.

website:http://www.massivechem.com/

Contact:+86 21 34943721

Address:Room 435, 4th floor, Building 9, No. 2568 Gudai Road,Minhang District, Shanghai,
Shanghai Micro-mega Industry Co., Ltd.

Contact:0086-21-34628682;57153848

Address:Rm413,No.413,West Meilong Road, Minhang District,Shanghai P R China
Shanghai Dynamic Industrial Co.,Ltd.

website:http://www.shdynamic.com

Contact:86-021 3392 6680

Address:Room 805 Information Tower, No.1403 Minsheng Road, Pudong New Area, Shanghai 200135, P. R. China

Relevant to this article

Synthesis of [Ethylene-1-(η ⁵-4,5,6,7-tetrahydro-1-indenyl)-2-(η⁵-4′ ,5′,6′,7′-tetrahydro-2′-indenyl)]titanium Dichloride, the Elusive Isomer of the Brintzinger-Type ansa-Titanocenes

Doi:10.1021/jo034975o
(2003)
An expeditious synthesis of 3-(difluoromethoxy)- and 3-(trifluoromethoxy)-5,6,7,8-tetrahydro-1,6-naphthyridines

Doi:10.1016/j.tetlet.2008.08.083
(2008)
Dual targeting of cholinesterase and amyloid beta with pyridinium/isoquinolium derivatives

Doi:10.1002/ddr.21631
(2020)
Doi:10.1039/j39660000637
(1966)
Doi:10.1021/ja01338a052
(1933)
The Baylis-Hillman chemistry in aqueous media: Elucidation of mechanism for synthesis of ether side-product leads to an efficient approach to C-O bond formation

Doi:10.1016/S0040-4020(02)01561-2
(2003)

Article Doi