3-Substituted, 3-(4-pyridinylmethyl)-1,3-dihydro-1-phenyl-2H-indol-2-ones as acetylcholine release enhancers: Synthesis and SAR

DOI: 10.1021/jm00072a009

Source and publish data:

Journal of Medicinal Chemistry p. 2899 - 2907 (1993)

Update date:2022-08-05

Topics:

Authors:

Wilkerson

Kergaye Kergaye

Tam Tam

Read Full Text PDF DownLoad Join now for total 90,000,000 free articles

Article abstract of DOI:10.1021/jm00072a009

A series of 3-substituted, 3-(4-pyridinylmethyl)-1,3-dihydro-1-phenyl-2H- indol-2-ones was synthesized and found to enhance the stimulus-induced release of neurotransmitter acetylcholine (AcCh), and by doing so, might be useful in treating cognitive disor

Full text of DOI:10.1021/jm00072a009

Products guided by the article

Product name:2,3-dihydro-2-oxo-1-phenyl-3-(4-pyridinylmethyl)-1H-indole-3-butanoic acid ethyl ester

Cas No:150897-91-9

R&D Labs maybe for 150897-91-9

Suzhou Wedo Chemicals Co., Ltd.

Contact:86 512 58100425

Address:Zonger Road, DongSha Industry Park , Zhangjiagang, Jiangsu, China
Springchem New Material Technology Co.,Limited

website:http://www.spring-chem.com

Contact:86-21-62885108

Address:602B, Building 1, No. 641, Tianshan Road
JIEJIE GROUP CO.,LTD.

Contact:+86 021-51698675

Address:1701, Jielong Plaza, No.618 Pingliang Rd, ShangHai,China
Nanjing Vincero International Trading Co.,Ltd

Contact:8618936897229

Address:NO.68, ZhuShan Road, JiangNing WanDa Plaza, Building E Room 1703
Reliable Pharma Technology (Shanghai) Co., Ltd.

Contact:0086-21-67676847-8008

Address:Lane 1500, No.68, Xinfei Road, Songjiang District, Shanghai, 201611, P.R.China.

Relevant to this article

Synthesis of [Ethylene-1-(η ⁵-4,5,6,7-tetrahydro-1-indenyl)-2-(η⁵-4′ ,5′,6′,7′-tetrahydro-2′-indenyl)]titanium Dichloride, the Elusive Isomer of the Brintzinger-Type ansa-Titanocenes

Doi:10.1021/jo034975o
(2003)
An expeditious synthesis of 3-(difluoromethoxy)- and 3-(trifluoromethoxy)-5,6,7,8-tetrahydro-1,6-naphthyridines

Doi:10.1016/j.tetlet.2008.08.083
(2008)
Dual targeting of cholinesterase and amyloid beta with pyridinium/isoquinolium derivatives

Doi:10.1002/ddr.21631
(2020)
Doi:10.1039/j39660000637
(1966)
Doi:10.1021/ja01338a052
(1933)
The Baylis-Hillman chemistry in aqueous media: Elucidation of mechanism for synthesis of ether side-product leads to an efficient approach to C-O bond formation

Doi:10.1016/S0040-4020(02)01561-2
(2003)

Article Doi