Tetrahedron Letters p. 6368 - 6370 (2008)
Update date:2022-08-05
Topics:
Guiadeen, Deodialsingh
Kothandaraman, Shankaran
Yang, Lihu
Mills, Sander G.
MacCoss, Malcolm
An expeditious and concise synthesis of 3-(difluoromethoxy)-5,6,7,8-tetrahydro-1,6-naphthyridine and 3-(trifluoromethoxy)-5,6,7,8-tetrahydro-1,6-naphthyridines is described. Starting from N-benzyl piperidone, the key intermediates leading to these two bio
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