Synthesis of 6-methoxy- and 6-chloro-2(1H)-pyridinone acyclo-C-nucleosides from 2H-1,4-oxazin-2-ones

Article abstract of DOI:10.1016/S0040-4020(01)89920-8

Starting from 6-variated 3-methoxy- and 3-chloro-2H-1,4-oxazin-2-ones 4a-e the synthesis of a series of 6-methoxy- and 6-chloro-2(1H)-pyridinone acyclo-C-nucleosides 2a-d and 3a-d was accomplished. Diels-Alder reaction of the oxazinones 4a-e with propargy