Synthesis and Structure-Activity Relationships of Naphthalene-Substituted Derivatives of the Allylamine Antimycotic Terbinafine

DOI: 10.1021/jm00071a011

Source and publish data:

Journal of Medicinal Chemistry p. 2810 - 2816 (1993)

Update date:2022-08-02

Topics: Synthesis Derivatives Naphthalene Structure-activity relationships Antimycotic

Authors:

Nussbaumer, Peter

Dorfstaetter, Gerhard

Leitner, Ingrid

Mraz, Karin

Vypel, Hermann

Stuetz, Anton

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Article abstract of DOI:10.1021/jm00071a011

Derivatives of the allylamine antimycotic terbinafine (1) with varied substitution at the naphthalene ring system have been prepared, and their antifungal activity has been evaluated.In general, the potency is strongly dependent on the bulkiness of the su

Full text of DOI:10.1021/jm00071a011

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