Journal of Medicinal Chemistry p. 7098 - 7112 (2014)
Update date:2022-08-15
Topics:
Long, Jing
Zhang, Shan-Feng
Wang, Pan-Pan
Zhang, Xue-Mei
Yang, Zhong-Jin
Zhang, Quan
Chen, Yue
The first total synthesis of parthenolide (1) is described. The key feature of this synthesis is the formation of a 10-membered carbocylic ring by a macrocyclic stereocontrolled Barbier reaction, followed by a photoinduced Z/E isomerization. The biological evaluation of a small library of parthenolide analogues (19, 33, and 34) disclosed a preliminary structure-activity relationship (SAR). The results revealed that the C1, C10 double bond configuration of parthenolide has little or no effect on the activity, and the C6 and C7 configurations of the lactone ring have a moderate impact on the activities against some cancer cell lines.
View MoreContact:+86-371-67759225
Address:No.32, Jinsuo Road, High-tech Zone
KA-SHING Business Trade Macau Co., Ltd.
Contact:00853-28430045
Address:23rd Floor, Block 3 La Cite, Areia Preta, Macao
website:http://www.mingchem.com/en/index
Contact:0519-85170101-802
Address:Fifth Floor,B of Beihua Buliding,520 Road of Science and Education City,Changwu middle road NO.801,Wujin District,Changzhou,Jiangsu province
Contact:+86-571-86025531 / 86024803
Address:1218-24 Guangyin Mansion,42 Fengqi East Road
Contact:+86-22-26358246
Address:601-4-20, Fujiayuan, Tiantai Road, Hebei District, Tianjin, China
Doi:10.1021/ol403326z
(2014)Doi:10.1007/s11172-013-0148-4
(2013)Doi:10.1016/0040-4020(68)88184-0
(1968)Doi:10.1055/s-2005-871953
(2005)Doi:10.1007/s11743-012-1349-9
(2012)Doi:10.1039/DT9930002933
(1993)