Mammalian topoisomerase II inhibitory activity of 1-cyclopropyl-6,8- difluoro-1,4-dihydro-7-(2,6-dimethyl-4-pyridinyl-4-oxo-3-quinolinecarboxylic acid and related derivatives

DOI: 10.1021/jm00071a010

Source and publish data:

Journal of Medicinal Chemistry p. 2801 - 2809 (1993)

Update date:2022-08-05

Topics:

Authors:

Wentland

Lesher Lesher

Reuman Reuman

Gruett Gruett

Singh Singh

Aldous Aldous

Dorff Dorff

Rake Rake

Coughlin

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Article abstract of DOI:10.1021/jm00071a010

1-Cyclopropyl-6,8-difluoro-1,4-dihydro-7-(2,6-dimethyl-4-pyridinyl)-4- oxo-3-quinolinecarboxylic acid (1), a previously reported potent inhibitor of bacterial DNA gyrase, was found to be interactive with mammalian topoisomerase II (topo II). In a DNA-clea

Full text of DOI:10.1021/jm00071a010

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