Bioorganic and Medicinal Chemistry Letters p. 2837 - 2842 (1997)
Update date:2022-09-26
Topics:
Rana, Vipul S.
Kumar, Vaijayanti A.
Ganesh, Krishna N.
The synthesis of oligonucleotides containing chiral acyclic 2(R/S)-(N- thymin-1-ylacetyl)-amino-1 (R/S)-phenyl-1,3-propanediol unit in the backbone (I, R=Ar) is described. When used as third strand of a triplex with complementary natural duplex, the modified oligonucleotides form stable triplexes with triplex <=> duplex transition Tm dependent on the number, position and stereochemistry of modification.
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