Synthesis of 3-aminopyrrolo[2,1-a]isoquinoline, 3-aminopyrrolo[2,1-a]phthalazine, and 7-aminopyrrolo[1,2-b]pyridazine derivatives

Article abstract of DOI:10.1055/s-1993-25905

A simple route to 3-aminopyrrolo[2,1-a]isoquinoline, 3-aminopyrrolo[2,1-a]phthalazine, and 7-aminopyrrolo[1,2-b]pyridazine derivatives 8a, 8b and 11, respectively, is described, based on displacement of a chlorine atom in the appropriate precursors with benzylamine. The chloro-substituted precursors were prepared by using a tandem dichlorocarbene/cycloimmonium ylide approach.