Convenient and Regioselective Syntheses of 3,4-Disubstituted Δ3-Pyrrolin-2-ones Derivatives Starting from 2-Tosyl-3,4-Disubstituted Pyrroles

Article abstract of DOI:10.1246/cl.1993.1437

3,4-Disubstituted Δ³-pyrrolin-2-ones were prepared in high yields via 5-tosyl-Δ³-pyrrolin-2-ones (4) starting from 2-tosylpyrroles regioselectively.The compounds 4 were found to be useful intermediates for the preparation of variety of Δ³-pyrrolin-2-one derivatives.The reactions of 4 with various nucleophiles and active methylene compounds bearing an appropriate leaving group are described.