Stereoselective Total Synthesis of Polyether Ionophore Antibiotics, Isolasalocid A and Lasalocid A. Part 2. The Total Synthesis via Stereoselective Construction of the B Rings by Chelation-Controlled Cyclization under Thermodynamic Conditions

Article abstract of DOI:10.1016/S0040-4020(01)87185-4

Stereoselective total synthesis of isolasalocid A (1) and lasalocid A (2) was achieved via construction of the tetrahydrofuran rings by chelation-controlled cyclization of the corresponding p-methoxyphenyl substituted allyl alcohols (6, 7) under thermodyn