(2S,3S)-2-Amino-3-(2,2-diphenylethyl)pentanedioic acid selective group 2 metabotropic glutamate receptor antagonist

DOI: 10.1016/S0960-894X(98)00091-2

Source and publish data:

Bioorganic and Medicinal Chemistry Letters p. 765 - 770 (1998)

Update date:2022-08-05

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Authors:

Escribano, Ana

Ezquerra, Jesus

Pedregal, Concepcion

Rubio, Almudena

Yruretagoyena, Belen

Baker, S. Richard

Wright, Rebecca A.

Johnson, Bryan G.

Schoepp, Darryle D.

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Article abstract of DOI:10.1016/S0960-894X(98)00091-2

(2S,4S)-2-Amino-4-(4,4-diphenylbut-1-yl)-pentane-1,5-dioic acid 1m, is a novel metabotropic glutamate receptor (mGluR) antagonist with insignificant ionotropic affinity. It is a selective antagonist of negatively-coupled cAMP-linked mGluRs with no effect

Full text of DOI:10.1016/S0960-894X(98)00091-2

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