Isosteric phosphonate analogs of ET-16-OMe. Synthesis and biological evaluation of the enantiomers of 2'-(trimethylammonio)ethyl 4-(hexadecyloxy)- 3-methoxybutanephosphonate and 2'-(trimethylammonio)ethyl 4-(hexadecylthio)- 3-methoxybutanephosphonate

DOI: 10.1021/jm00029a016

Source and publish data:

Journal of Medicinal Chemistry p. 425 - 430 (1994)

Update date:2022-08-03

Topics:

Authors:

Bittman Bittman

Byun Byun

Mercier Mercier

Salari Salari

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Article abstract of DOI:10.1021/jm00029a016

The enantiomers of two isosteric phosphonate analogs of the ether-linked antitumor agent 1-O-octadecyl-2-O-methyl-sn-glycero-3-phosphocholine (ET-18- OMe) were synthesized and evaluated for their cytotoxicity against various mouse leukemic cell lines in v

Full text of DOI:10.1021/jm00029a016

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