Conformational analysis of 5-lipoxygenase inhibitors: Role of the substituents in chiral recognition and on the active conformations of the (methoxyalkyl)thiazole and methoxytetrahydropyran series

DOI: 10.1021/jm00027a014

Source and publish data:

Journal of Medicinal Chemistry p. 113 - 124 (1994)

Update date:2022-09-26

Topics:

Authors:

Lambert-van der Brempt

Bruneau Bruneau

Lamorlette

Read Full Text PDF DownLoad Join now for total 90,000,000 free articles

Article abstract of DOI:10.1021/jm00027a014

The investigation of the SAR of 5-lipoxygenase (5-LO) inhibition of a series of racemic (methoxyalkyl)thiazoles, exemplified by compound 7 (ZM- 211965), has led to other active, racemic derivatives in which the thiazole moiety has been replaced by an este

Full text of DOI:10.1021/jm00027a014

Products guided by the article

Product name:(R)-(-)-2-<3-(benzyloxy)-5-fluorophenyl>-2-methoxybutanol

Cas No:153441-15-7

R&D Labs maybe for 153441-15-7

Shanghai Bojing Chemical Co., Ltd.

Contact:021-37122233

Address:6F Buildiing 11,No.388,Baifu Road,District Fengxian.Shanghai, China.
KindChem Co.,Ltd,

Contact:+86-25-85281586

Address:13F,Bld2#,South of Longpan Road
Suzhou JMS Chemical Co., Ltd.

Contact:+86-15995924277

Address:WuZhongOu suzhou new south road 89
zhangjiagang bonded areas banggao co;ltd

website:http://www.shunchangchem.com

Contact:0086-13921972933

Address:Dongsha Chemical Zone.Zhangjiagang, Jiangsu Province
Guangxi Nanning Guangtai Agriculture Chemical Co.,Ltd

Contact:+86-771-2311266

Address:Room703,Building12, Software Park Phase II,NO.68,Keyuan Road,Nanning City,Guangxi,China

Relevant to this article

2'-O,5-dimethyluridine: A total synthesis and single crystal X-ray diffraction study

Doi:10.1002/jhet.5570300522
(1993)
Silver-catalyzed decarboxylative homocoupling reaction for the construction of tetrafluoroethylene-bridging aromatic compounds

Doi:10.1080/00397911.2019.1651865
(2019)
Self-reproduction of chirality. Asymmetric synthesis of β-alkyl-β-amino acids from enantiomerically pure dihydropyrimidinones

Doi:10.1016/0040-4020(93)80005-E
(1993)
Amidation reactions from the direct coupling of metal carboxylate salts with amines

Doi:10.1021/jo402374c
(2014)
Synthesis and Reactions of 3,4-Bis(trimethylsilyl)furan: Diels-Alder Cycloaddition, Friedel-Crafts Acylation, and Regiospecific Conversion to 3,4-Disubstituted Furans

Doi:10.1021/jo00093a025
(1994)
Substrate control in enantioselective and diastereoselective aldol reaction by memory of chirality: A rapid access to enantiopure β-hydroxy quaternary α-amino acids

Doi:10.1021/ol403523e
(2014)

Article Doi