Conformational analysis of 5-lipoxygenase inhibitors: Role of the substituents in chiral recognition and on the active conformations of the (methoxyalkyl)thiazole and methoxytetrahydropyran series

DOI: 10.1021/jm00027a014

Source and publish data:

Journal of Medicinal Chemistry p. 113 - 124 (1994)

Update date:2022-09-26

Topics:

Authors:

Lambert-van der Brempt

Bruneau Bruneau

Lamorlette

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Article abstract of DOI:10.1021/jm00027a014

The investigation of the SAR of 5-lipoxygenase (5-LO) inhibition of a series of racemic (methoxyalkyl)thiazoles, exemplified by compound 7 (ZM- 211965), has led to other active, racemic derivatives in which the thiazole moiety has been replaced by an este

Full text of DOI:10.1021/jm00027a014

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