2'-O,5-dimethyluridine: A total synthesis and single crystal X-ray diffraction study

Article abstract of DOI:10.1002/jhet.5570300522

A new method for the synthesis of 2'-O,5-dimethyluridine (5) has provided the title compound in a higher yield. Application of a one-pot ribosylation methodology resulted in an efficient, high yield synthesis of 5-methyluridine (ribothymine, 3b). An X-ray diffraction analysis of 5 disclosed the conformation of the sugar moiety of this nucleoside as anti, N(3'-endo), g⁺.