Preparation of α-Methylene and α-Ethylidene β-Lactams via the Ester Enolate-Imine Condensation Using β-(Dialkylamino) Esters as Starting Materials: Scope and Synthetic Applications

DOI: 10.1021/jo00105a013

Source and publish data:

Journal of Organic Chemistry p. 7994 - 8002 (1994)

Update date:2022-08-03

Topics:

Authors:

Alcaide, Benito

Esteban, Gemma

Martin-Cantalejo, Yolanda

Plumet, Joaquin

Rodriguez-Lopez, Julian

et al. et al.

Read Full Text PDF DownLoad Join now for total 90,000,000 free articles

Article abstract of DOI:10.1021/jo00105a013

A new, simple procedure for the preparation of appropriately substituted α-methylene and α-ethylidene β-lactams via the ester enolate-imine condensation is described.The method is based on the use of lithium 3-(dialkylamino) ester enolates as synthetic eq

Full text of DOI:10.1021/jo00105a013

Products guided by the article

Product name:(Z)-3-ethylidene-1-(4-methoxyphenyl)-4-phenylazetidin-2-one

Cas No:153469-87-5

R&D Labs maybe for 153469-87-5

XI'AN CHUKANG BIOTECHNOLOGY CO.,LTD

Contact:29-63685658 63685359

Address:Room 3-1202,Building 1,Oriental oasis,East of Xianning Road,Xi'an,Shaanxi 710043 P.R.China
Nantong Kaixin Pharma Chemical Co.,Ltd.

Contact:86-513-85250786

Address:2-1103 Huachen Mansion, 111 Gongnong Road,Nantong, Jiangsu, China
Taixing Joxin Bio-tec Co.,Ltd.

website:http://www.joxbio.com

Contact:86-523-87558858 87612088

Address:No.88, chengdong industrial park
Shanghai birch chemical technology co.,ltd

Contact:+86-21-54096810

Address:No.2588,Jungong Road,Shanghai,China
Shanghai Xinda Pharmaceuticals Co., Ltd.

Contact:86-21-33692333-8008

Address:999 Linxian Road, Jinshan Industrial Park, Shanghai, China

Relevant to this article

Annulation with methyl 4-(triphenylphosphoranylidene)acetoacetate. Application to the synthesis of a 1,3-benzenedicarboxylate derivative

Doi:10.1080/00397919308013806
(1993)
Palladium-catalyzed reactions of allyl acetates with N-substituted 4-trimethylstannyl-1,2,3,6-tetrahydropyridines

Doi:10.1134/S1070428013120269
()
Novel hybrids derived from aspirin and chalcones potently suppress colorectal cancer in vitro and in vivo

Doi:10.1039/C8MD00284C
(2018)
Lipase YS-Catalyzed Enantioselective Transesterification of Alcohols of Bicarbocyclic Compounds

Doi:10.1246/bcsj.66.573
(1993)
Sulfur-directed regioselective radical cyclization leading to β-lactams: Formal synthesis of (±)-PS-5 and (+)-thienamycin

Doi:10.1021/jo00110a035
(1995)
Chemosensing of nitroaromatics with a new segmented conjugated quaterphenylene polymer

Doi:10.1016/j.tetlet.2011.07.055
(2011)

Article Doi