Dianilinophthalimides: Potent and selective, ATP-competitive inhibitors of the EGF-receptor protein tyrosine kinase

DOI: 10.1021/jm00033a019

Source and publish data:

Journal of Medicinal Chemistry p. 1015 - 1027 (1994)

Update date:2022-08-04

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Authors:

Trinks Trinks

Buchdunger

Furet Furet

Kump Kump

Mett Mett

Meyer Meyer

Muller Muller

Regenass

Rihs Rihs

Lydon Lydon

Traxler Traxler

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Article abstract of DOI:10.1021/jm00033a019

Dianilinophthalimides represent a novel class of inhibitors of the EGF- receptor protein tyrosine kinase with a high degree of selectivity versus other tyrosine and serine/threonine kinases. Steady-state kinetic analysis of compound 3, which showed potent

Full text of DOI:10.1021/jm00033a019

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