Journal of the American Chemical Society
Communication
Na, R.; Wang, B.; Liu, H.; Zhang, L.; Liu, J.; Wang, M.; Zhong, J.;
Kwon, O.; Guo, H. Adv. Synth. Catal. 2012, 354, 1023−1034.
(16) Enals were previoulsy used as 1,3-dipolar substates (via
homoenolate intermediates) in cylcoaddition reactions; for examples,
see: (a) Lv, H.; Jia, W.-Q.; Sun, L.-H.; Ye, S. Angew. Chem., Int. Ed.
2013, 52, 8607−8610. (b) Izquierdo, J.; Orue, A.; Scheidt, K. A. J. Am.
Chem. Soc. 2013, 135, 10634−10637.
ACKNOWLEDGMENTS
■
Generous financial support for this work is provided by
Singapore National Research Foundation, Singapore Economic
Development Board, GlaxoSmithKline, and Nanyang Techno-
logical University (NTU). We thank Dr. Y. Li and Dr. R.
Ganguly (NTU) for X-ray structure analysis.
(17) NHC-catalyzed oxidation of γ-carbon activation of enals, see:
(a) Mo, J.; Chen, X.; Chi, Y. R. J. Am. Chem. Soc. 2012, 134, 8810−
8813. (b) Chen, X.; Yang, S.; Song, B. A.; Chi, Y. R. Angew. Chem., Int.
Ed. 2013, 52, 11134−11137.
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