Nucleic acid related compounds. 80. Synthesis of 5'-S-(alkyl and aryl)-5'-fluoro-5'-thioadenosines with Xenon difluoride or (diethylamido)sulfur trifluoride, hydrolysis in aqueous buffer, and inhibition of S-adenosyl-L-homocysteine hydrolase by derived 'a

Article abstract of DOI:10.1021/jo00082a010

Treatment of 5'-S-(alkyl and aryl)-5'-thioadenosine derivatives 2 with XeF₂, or the corresponding sulfoxides 3 with DAST/SbCl₃, gave diastereomeric 5'-fluoro compounds which were deprotected to give the 5'-S-(alkyl and aryl)-5'-fluor