Construction of Chiral 2-functionalized Piperidine via Enzymatic Resolution and Palladium-catalyzed N-Alkylation

DOI: 10.1246/cl.1994.21

Source and publish data:

Chemistry Letters p. 21 - 22 (1994)

Update date:2022-07-29

Topics:

Authors:

Hirai, Yoshiro

Nagatsu, Mayumi

Read Full Text PDF DownLoad Join now for total 90,000,000 free articles

Article abstract of DOI:10.1246/cl.1994.21

The palladium-catalyzed cyclization of the optically active urethan <(-)-1>, which was obtained by enzymatic resolution of the racemic alcohol (1), gave the piperidine 6.This reaction affords highly efficient intramolecular chirality transfer.Compound 6 was converted into (+)-coniine and 2-hydroxymethylpiperidine.

Full text of DOI:10.1246/cl.1994.21

Products guided by the article

Product name:Acetic acid (E)-(R)-7-benzyloxycarbonylamino-1-methyl-hept-2-enyl ester

Cas No:154499-15-7

R&D Labs maybe for 154499-15-7

Shanghai Science Peptide Biological Technology Co.,ltd

website:http://www.scipeptide.com

Contact:+86-21-51099675

Address:No.8 Changyang Rd
Hunan Shineway Enterprise Co., Ltd.

Contact:+86-731-86303875

Address:118, Huanghua International Airport Road, Huanghua Town, Changsha, Hunan 410137, China
Nanjing Legend Pharmaceutical & Chemical Co., Ltd.

Contact:+86-25-83767696

Address:14-7 Zhongshan Lu Guluo District, Nanjing
Fiarpharmatech Co., Ltd.(expird)

Contact:13482436141

Address:Room 1138, Building 3, No. 555, Huancheng Road(West), Fenxian District, Shanghai
Sichuan Highlight Fine Chemicals Co., Ltd.

Contact:+86-28-8525 1605

Address:A5-102 Airport base,388 West Airport Huang He Zhong Lu,2 Section

Relevant to this article

Ruthenium-catalyzed meta/ortho-selective C-H alkylation of azoarenes using alkyl bromides

Doi:10.1039/C6CC09323J
(2017)
Assembly of tetranuclear ruthenium complexes with planar metal core by condensation of two diruthenium units using bridging ligands: Synthesis and molecular structure of [Ru₄(CO)₈{μ₂-P(Cy)₂}₄] and [Ru₄(CO)₈{μ₄-P(Cy)}₂{μ₂-P(Cy)₂}₂] (Cy = cyclohexyl)

Doi:10.1002/hlca.19940770213
(1994)
Analogues of azepinomycin: Inhibitors of guanase

Doi:10.1080/15257779508012405
(1995)
Preparation and properties of chloro-3-methoxycatechols-components of pulp bleaching effluents

Doi:10.1016/0045-6535(94)90008-6
(1994)
A New Enantioselective Synthesis of trans 2,5-Disubstituted Pyrrolidine Derivatives by Radical Cyclisation

Doi:10.1039/c39940000455
(1994)
Intramolecular nitrogen delivery for the synthesis of C-glycosphingolipids. Application to the C-glycoside of the immunostimulant KRN7000

Doi:10.1021/ol5002686
(2014)

Article Doi