Construction of Chiral 2-functionalized Piperidine via Enzymatic Resolution and Palladium-catalyzed N-Alkylation

Article abstract of DOI:10.1246/cl.1994.21

The palladium-catalyzed cyclization of the optically active urethan <(-)-1>, which was obtained by enzymatic resolution of the racemic alcohol (1), gave the piperidine 6.This reaction affords highly efficient intramolecular chirality transfer.Compound 6 was converted into (+)-coniine and 2-hydroxymethylpiperidine.