Construction of Chiral 2-functionalized Piperidine via Enzymatic Resolution and Palladium-catalyzed N-Alkylation

DOI: 10.1246/cl.1994.21

Source and publish data:

Chemistry Letters p. 21 - 22 (1994)

Update date:2022-07-29

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Authors:

Hirai, Yoshiro

Nagatsu, Mayumi

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Article abstract of DOI:10.1246/cl.1994.21

The palladium-catalyzed cyclization of the optically active urethan <(-)-1>, which was obtained by enzymatic resolution of the racemic alcohol (1), gave the piperidine 6.This reaction affords highly efficient intramolecular chirality transfer.Compound 6 was converted into (+)-coniine and 2-hydroxymethylpiperidine.

Full text of DOI:10.1246/cl.1994.21

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