A concise diastereoselective synthesis of the natural (2R, 3S)2-hydroxymethyl-3-hydroxy pyrrolidine

DOI: 10.1016/0040-4039(94)88178-2

Source and publish data:

Tetrahedron Letters p. 119 - 122 (1994)

Update date:2022-07-31

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Authors:

Griffart-Brunet, Dominique

Langlois, Nicole

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Article abstract of DOI:10.1016/0040-4039(94)88178-2

(2R, 3S)-2-hydroxymethyl-3-hydroxy pyrrolidine 4, a constituent of CAstanospermum ausfrale, 1 was synthesized from (S)-pyroglutamic acid through diastereoselective epoxidation of α, β-unsaturated pyrrolidone 8.

Full text of DOI:10.1016/0040-4039(94)88178-2

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